Solid-state carbon NMR characterization and investigation of intrinsic dissolution behavior of fluconazole polymorphs, anhydrate forms 1 and 2
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- Park Hee Jun
- Center for Nanotechnology-Based New Drug Dosage Form, College of Pharmacy, Chungnam National University
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- Kim Min-Soo
- Center for Nanotechnology-Based New Drug Dosage Form, College of Pharmacy, Chungnam National University
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- Kim Jeong-Soo
- Center for Nanotechnology-Based New Drug Dosage Form, College of Pharmacy, Chungnam National University
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- Cho Wonkyung
- Center for Nanotechnology-Based New Drug Dosage Form, College of Pharmacy, Chungnam National University
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- Park Junsung
- Center for Nanotechnology-Based New Drug Dosage Form, College of Pharmacy, Chungnam National University
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- Cha Kwang-Ho
- Center for Nanotechnology-Based New Drug Dosage Form, College of Pharmacy, Chungnam National University
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- Kang Young-Shin
- Center for Nanotechnology-Based New Drug Dosage Form, College of Pharmacy, Chungnam National University
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- Hwang Sung-Joo
- Center for Nanotechnology-Based New Drug Dosage Form, College of Pharmacy, Chungnam National University
書誌事項
- タイトル別名
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- Solid-State Carbon NMR Characterization and Investigation of Intrinsic Dissolution Behavior of Fluconazole Polymorphs, Anhydrate Forms I and II
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Solid-state 13C nuclear magnetic resonance (13C-SSNMR) revealed significant differences in the chemical shift of specific carbon atoms between two fluconazole polymorphs, reflecting a change in molecular conformation. A single resonance signal without splitting was observed in the spectrum of anhydrate form II, while the spectrum of anhydrate form I showed signals with splitting, indicating the presence of two dissimilar molecular conformations in the unit cell of anhydrate form I. The Fourier transform infrared (FT-IR) and Raman spectra associated with the triazole group, the 2,4-difluorobenzyl group, and the propane backbone provided also evidence of structural differences between forms I and II accompanying with 13C-SSNMR. 1H T1 relaxation times, measured using saturation recovery experiments, showed that the metastable anhydrate form II was more mobile than the stable form I. The solubility and intrinsic dissolution tests showed that the anhydrate form II was more soluble and dissolved faster than the anhydrate form I.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 58 (9), 1243-1247, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204172946816
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- NII論文ID
- 130000324604
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 10796507
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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