Phragmalin-Type Limonoid Orthoesters from Chukrasia tabularis var. velutina

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  • Luo Jun
    Department of Natural Medicinal Chemistry, China Pharmaceutical University
  • Wang Jun-Song
    Department of Natural Medicinal Chemistry, China Pharmaceutical University
  • Wang Xiao-Bing
    Department of Natural Medicinal Chemistry, China Pharmaceutical University
  • Luo Jian-Guang
    Department of Natural Medicinal Chemistry, China Pharmaceutical University
  • Kong Ling-Yi
    Department of Natural Medicinal Chemistry, China Pharmaceutical University

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Nine new phragmalin-type limonoid orthoesters, tabulalides F—N (1—9), together with three known compounds, tabulalides C and D, and tabularisin N (10—12), were isolated from the stem bark of Chukrasia tabularis var. velutina. Extensive spectroscopic technologies were applied to elucidate the structures of these new compounds, including the application of circular dichroism (CD) exciton chirality method for the determination of the absolute configurations of 1 and 2. Tabulalide F (1) has a rare orthoisobutylate moiety in phragmalin-type limonoid orthoesters. These compounds were evaluated for cytotoxic activity against five human cancer cell lines in vitro. Tabulalide G (2) exhibts moderate cytotoxic activity against MCF-7 with IC50 value of 20.4 μmol/l, and other compounds have weak inhibitory effects on the growth of tested tumor cells.

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