Novel Nortriterpenoids from Aphanamixis grandifolia
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- Zhang Yao
- Department of Natural Medicinal Chemistry, China Pharmaceutical University
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- Wang Jun-Song
- Department of Natural Medicinal Chemistry, China Pharmaceutical University
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- Luo Jun
- Department of Natural Medicinal Chemistry, China Pharmaceutical University
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- Kong Ling-Yi
- Department of Natural Medicinal Chemistry, China Pharmaceutical University
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Abstract
Four novel nortriterpenoids, 24,25-epoxy-tirucall-7,20(E)-diene-3,23-dione (1), 24,25,26,27-tetranortirucall-1,7-diene-23(21)-lactone (2), 3α-hydroxy-tirucall-7-ene-20-one (3), and 3-oxo-tirucall-7-ene-3,20-dione (4), together with one known compound mombasol (5) were isolated from the stem barks of Aphanamixis grandifolia. Their structures were elucidated on the basis of various spectroscopic analysis including electrospray ionization (ESI)-MS, high resolution (HR)-ESI-MS, IR, 1D- and 2D-NMR techniques (heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond connectivity (HMBC) and rotating frame Overhauser enhancement spectroscopy (ROESY)), and by comparison of their spectral data with those reported. The absolute configuration of compound 1 was determined by circular dichroism (CD) exciton chirality.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 59 (2), 282-286, 2011
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204173109632
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- NII Article ID
- 130000405529
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 10951954
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed