Synthesis, crystal structure, antioxidant activity, and DNA-binding studies of a novel Ni(2) 〔2×2〕 grid complex with a rigid bistridentate Schiff base ligand

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  • Jia Lei
    Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University Department of Physics and Chemistry, Henan Polytechnic University
  • Xu Jun
    Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University
  • Xu Xi-Ming
    School of Life Science, Lanzhou University
  • Chen Long-Hai
    Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University
  • Jiang Peng
    School of Life Science, Lanzhou University
  • Cheng Fei-Xiang
    Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University
  • Lu Guang-Nong
    Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University
  • Wang Qin
    School of Life Science, Lanzhou University
  • Wu Jin-Cai
    Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University
  • Tang Ning
    Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University

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  • Synthesis, Crystal Structure, Antioxidant Activity, and DNA-Binding Studies of a Novel Ni(II) [2*2] Grid Complex with a Rigid Bistridentate Schiff Base Ligand
  • Synthesis crystal structure antioxidant activity and DNA binding studies of a novel Ni 2 2 2 grid complex with a rigid bistridentate Schiff base ligand

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With a bistridentate Schiff-base ligand, N′,N′3-bis[(1E)-1-(2-pyridinyl)ethylidene)] isophthalohydrazide (H2L), a [2×2]G grid complex, [Ni4(HL)4](ClO4)4·4H2O·0.5 CH3OH (1) has been synthesized and characterized spectroscopically and crystallographically. Spectrometric titrations, ethidium bromide displacement experiments, circular dichroism spectral analysis and viscosity measurements indicate that the compound 1 strongly binds with calf-thymus DNA, presumably via intercalation mechanism. Furthermore, the antioxidant activity (superoxide and hydroxyl radical) of the ligand and its nickel(II) complex is determined by using spectrophotometer methods in vitro. Complex 1 is found to possess potent antioxidant activity and be better than standard antioxidants like mannitol.

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