Assessment of processing and polymorphic form effect on the powder and tableting properties of microcrystalline celluloses 1 and 2
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- Rojas John
- Department of Pharmacy, School of Pharmaceutical Chemistry, The University of Antioquia
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- López Alvin
- Department of Pharmacy, School of Pharmaceutical Chemistry, The University of Antioquia
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- Gamboa Yudy
- Department of Pharmacy, School of Pharmaceutical Chemistry, The University of Antioquia
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- González Christian
- Department of Pharmacy, School of Pharmaceutical Chemistry, The University of Antioquia
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- Montoya Fernando
- Department of Pharmacy, School of Pharmaceutical Chemistry, The University of Antioquia
書誌事項
- タイトル別名
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- Assessment of Processing and Polymorphic Form Effect on the Powder and Tableting Properties of Microcrystalline Celluloses I and II
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Microcrystalline cellulose I (MCCI) is an excipient used as a diluent, disintegrant, glidant and binder for the production of pharmaceutical tablets. In this work, microcrystalline cellulose II (MCCII) was obtained from cotton fibers by basic treatment with 7.5 N NaOH followed by an acid hydrolysis. MCCI and MCCII materials were processed by wet granulation, dry granulation and spray drying. Either the polymorphic form or processing had no effects on the particle morphology or particle size. However, MCCII powders had a higher porosity, less packing tendency, degree of crystallinity, degree of polymerization and density, but a faster disintegration than MCCI. The tensile strength of MCCI was highly affected by the wet and dry granulation processes. Most of the resulting powder and tableting properties were dependent on the polymorphic form of cellulose, rather than on the processing employed.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 59 (5), 603-607, 2011
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204173346176
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- NII論文ID
- 130000648875
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 11058071
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可