Studies on tertiary amine oxides-31-Reactions of aromatic N-oxides with antipyrine in the presence of acylating agents
書誌事項
- タイトル別名
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- Studies on Tertiary Amine Oxides. XXXI. Reactions of Aromatic N-Oxides with Antipyrine in the Presence of Acylating Agents.
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抄録
Antipyrine (I) was shown to react smoothly with quinoline 1-oxide (II), 4-chloroquinoline 1-oxide (VII) and isoquinoline 2-oxide (IX) in the presence of benzoyl chloride, producing 4-(2-quinolyl) antipyrine (III) (63.4%) together with 4-(4-quinolyl) antipyrine (IV) (16.4%), 4-(4-chloro-2-quinolyl) antipyrine (VIII) (88%) and 4-(1-isoquinolyl) antipyrine (X) (79%), respectively. Although tosyl chloride was not effective as an acylating agent for these reactions, methosulfate of II could enter into reaction with I to give III in 38.4% yield. Nucleophilic reactivity of I was considerably lower compared with that of cyclohexanone enamine, and no satisfactory result was obtained from similay treatment of pyridine 1-oxide.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 15 (9), 1380-1384, 1967
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204173525248
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- NII論文ID
- 110003620343
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 8509225
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- PubMed
- 5583713
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可