Pep-1 Peptide-Modified Liposomal Carriers for Intracellular Delivery of Gold Nanoparticles
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- Kang Myung Joo
- College of Pharmacy, Chung-Ang University
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- Lee Sangyeop
- Department of Bionano Engineering, Hanyang University
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- Kim Bo Kyun
- College of Pharmacy, Chung-Ang University
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- Eum Jae Yoon
- College of Pharmacy, Chung-Ang University
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- Park Sang Han
- College of Pharmacy, Chung-Ang University
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- Kang Min Hyung
- College of Pharmacy, Chung-Ang University
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- Oh Chil Hwan
- College of Medicine, Korea University
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- Choo Jaebum
- Department of Bionano Engineering, Hanyang University
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- Choi Young Wook
- College of Pharmacy, Chung-Ang University
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Abstract
A Pep-1 peptide-modified liposomal (Pep1-Lipo) carrier system was investigated to increase the intracellular delivery of gold nanoparticles (Au NPs). Au NPs with a mean diameter of 13 nm were successfully encapsulated into the inner aqueous compartment of the novel carrier using an ethanol injection technique, reserving the distinctive optical characteristics of the surface plasmon resonance peak around 530 nm. The Au NP-loaded liposomal carrier was physically characterized as 150—170 nm in size and 45 mV in zeta potential. Dark field microscopic observation demonstrated that in vitro cellular association and/or translocation of the nanoprobes into the cells was increased by Pep1-Lipo carriers compared to bare Au NPs. In conclusion, this novel liposomal formulation is a promising platform for the intracellular delivery of metallic nanoprobes including Au NPs.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 59 (1), 109-112, 2011
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204173842048
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- NII Article ID
- 130000405498
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 10927466
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed
