Steroid Series. XVIII. Acid-Catalysed Rearrangement Product of 3α, 5α-Cyclo-6, 19-dioxosteroid and its Conversion to 19-Nor-A-homotestosterone

DOI Web Site Web Site PubMed

Bibliographic Information

Other Title
  • Steroid series.-18-Acid-catalysed rearrangement product of 3α,5α-cyclo-6,19-dioxosteroid and its conversion to 19-nor-A-homotestosterone
  • Steroid series. 18 Acid-catalysed rearrangement product of 3 アルファ , 5 アルファ-cyclo-6 , 19-dioxosteroid and its conversion to 19-nor-A-homotestosterone

Search this article

Abstract

Treatment of 3α, 5α-cyclo-6, 19-dioxosteroid (II) in a boiling mixture of diluted sulfuric and acetic acids afforded 1β, 4β-oxido-6-oxo-Δ5 (10)-A-homo-19-norsteroid (III), together with a small amount of 3β-acetoxy-6, 19-dioxosteroid (IV), the latter compound, under the same reaction conditions, being converted to the former. The structure of the rearrangement product (III) was discussed. A-homo-19-nortestosterone (XXV) was synthesized from 1β, 4β-oxido-17β-hydroxy-A-homo-19-norandrost-5 (10)-en-6-one acetate (III : R=[chemical formula]).

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top