Flavonoid Glycosides from Chromolaena odorata Leaves and Their in Vitro Cytotoxic Activity

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  • Hung Tran Manh
    College of Pharmacy, Catholic University of Daegu Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama
  • Cuong To Dao
    College of Pharmacy, Catholic University of Daegu Institute of Natural Product Chemistry, Vietnamese Academic of Science and Technology
  • Dang Nguyen Hai
    Institute of Natural Product Chemistry, Vietnamese Academic of Science and Technology
  • Zhu Shu
    Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama
  • Long Pham Quoc
    Institute of Natural Product Chemistry, Vietnamese Academic of Science and Technology
  • Komatsu Katsuko
    Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama
  • Min Byung Sun
    College of Pharmacy, Catholic University of Daegu

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Two new flavonoid glycosides, (1, 2), and eleven known compounds, (3—13), were isolated from from a 70% EtOH extract of the leaves of Chromolaena odorata (Asteraceae). Their structures were elucidated by 1D and 2D NMR spectroscopic interpretation as well as by chemical studies. The newly isolated compounds were tested in vitro for their cytotoxic activities against the LLC and HL-60 cancer cell lines. Compound 1 showed cytotoxicity against LLC and HL-60 cancer cell lines with IC50 values of 28.2 and 11.6 μM, respectively. Compound 2 exhibited significant cytotoxic activity in the inhibition of HL-60 cancer cell lines with IC50 value of 10.8 μM.

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