On the Reaction of 4-Quinazolinecarbonitrile with Nucleophilic Reagents. III. Reaction of 4-Quinazolinecarbonitrile with Ketones
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- 東野 武郎
- Shizuoka College of Pharmacy
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説明
Reactions of 4-quinazolinecarbonitrile (I) with ketones in the presence of 50% sodium hydroxide were carried out in order to elucidate the chemical properties of (I). With acetone afforded 1-(4-quinazolinyl)-2-propanone (II), with 2-butanone, 1-(4-quinazolinyl)-2-butanone (III) and 4-ethylquinazoline (IV), with 3-pentanone (IV), with 3-methyl-2-butanone, 1-(4-quinazolinyl)-3-methyl-2-butanone (V) and 4-isopropylquinazoline (VI), with acetophenone, 2-(4-quinazolinyl) acetophenone (VII), with propiophenone, (IV) and benzoic acid (VIII), w ith cyclohexanone, 4-quinazolinehexanoic acid (IX), and with cyclopentanone, 2-(4-quinazolinyl) cyclopentanone (X). The foregoing experiments showed that the 4-position in (I) was very reactive to anionoid reagents, as already demonstrated in Part I and II of this series.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 10 (11), 1048-1052, 1962
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204174426624
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- NII論文ID
- 110003618760
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- PubMed
- 13954396
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可