Steroidal Sapogenins and Glycosides from the Fibrous Roots of Ophiopogon japonicus and Liriope spicata var. prolifera with Anti-inflammatory Activity

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  • Qi Jin
    Department of Complex Prescription of TCM, China Pharmaceutical University
  • Hu Zheng-fang
    Department of Complex Prescription of TCM, China Pharmaceutical University Nanjing Hailing Pharmaceutical Co., Ltd., Yangtze River Pharmaceutical Group
  • Zhou Yi-feng
    Department of Complex Prescription of TCM, China Pharmaceutical University
  • Hu Yuan-jia
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau
  • Yu Bo-yang
    Department of Complex Prescription of TCM, China Pharmaceutical University

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  • Steroidal Sapogenins and Glycosides from the Fibrous Roots of <i>Ophiopogon japonicus</i> and <i>Liriope spicata</i> var. <i>prolifera</i> with Anti-inflammatory Activity

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Two new steroidal glycosides (1 and 2), together with 15 known compounds (3–17) were isolated from the fibrous roots of Ophiopogon japonicus, and three new steroidal glycosides (18–20), together with 14 known compounds (21–34) were isolated from the fibrous roots of Liriope spicata var. prolifera. The structures of the new compounds were elucidated on the basis of extensive one-dimensional (1D)- and 2D-NMR spectroscopic analyses and mass spectrometry. The isolated compounds were evaluated for their anti-inflammatory activity in vitro. Most of these steroidal glycosides showed significant inhibitory activity against neutrophil respiratory burst stimulated by phorbol myristate acetate.

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