Reaction of Nitrogen Mustard with the Components of Ribonucleic Acid.

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Alexander stated that nitrogen mustard derivatives esterify the phosphoryl groups of deoxyribonucleic acid. Therefore, as the preliminary experiment, the present investigation deals with a discussion on the reaction products of 14C-labeled nitrogen mustard with nucleotides (adenylic acid, guanylic acid, and uridylic acid), nucleosides (adenosine, guanosine, uridine, and cytidine), and purine and pyrimidine bases (adenine, guanine, uracil, and cytosine) in a buffer solution. The data of analysis of these reaction mixtures by paper chromatography, electrophoresis, and autoradiography demonstrate that this alkylating agent reacts only with nucleotides, and not with the phosphorus-free components of ribonucleic acid. The present result seems to support the presumption that the most significant attack of alkylating agents on nucleic acid is the reaction with the phosphoryl groups.

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