Reaction of amide homologs,pt.5

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  • Reaction of Amide Homologs. V. Acetamidomethylation of Phenol and Anisole with N, N'-Methylenediacetamide.

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Acetamidomethylation of phenol and anisole was carried out by heating with N, N'-methylenediacetamide and phosphoryl chloride. Formation of N-(2-and 4-hydroxybenzyl) acetamides resulted in the case of phenol and formation of N-(4-methylbenzyl) acetamide in the case of anisole.

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