SYNTHESIS AND BIOLOGICAL ACTIVITIES OF BIOISOSTERIC O-CARBA-ANALOGUES OF PLATELET ACTIVATING FACTOR (PAF)
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説明
Four types of O-carba-analogues of C16-PAF were synthesized : d1-2-acetoxyeicosylphosphoryl choline (1), dl-3-hexadecyloxy-2-(2-oxopropyl) propylphosphoryl choline (2), d1-and (S)-(-)-3-acetoxy-4-hexa-decyloxybutylphosphonyl choline (3), and d1-2-acetoxy-3-hexadecyloxypropyl (3-trimethylammonio) propylphosphonate (4). Both in hypotension and in platelet aggregation, (S)-(-)-3 was one third as potent as synthetic C16-PAF, whereas 1, 2 and 4 were 100-3, 000 times less potent.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 32 (6), 2452-2455, 1984
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204177071744
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- NII論文ID
- 110003663619
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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