Bromopyrrole Alkaloids from a Marine Sponge <i>Agelas</i> sp.
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- Kusama Taishi
- Graduate School of Pharmaceutical Sciences, Hokkaido University
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- Tanaka Naonobu
- Graduate School of Pharmaceutical Sciences, Hokkaido University
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- Takahashi-Nakaguchi Azusa
- Medicinal Mycology Research Center, Chiba University
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- Gonoi Tohru
- Medicinal Mycology Research Center, Chiba University
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- Fromont Jane
- Western Australian Museum
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- Kobayashi Jun’ichi
- Graduate School of Pharmaceutical Sciences, Hokkaido University
Bibliographic Information
- Other Title
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- Bromopyrrole Alkaloids from a Marine Sponge Agelas sp
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Description
Five new bromopyrrole alkaloids, 2-bromokeramadine (1), 2-bromo-9,10-dihydrokeramadine (2), tauroacidins C (3) and D (4), and mukanadin G (5), were isolated from an Okinawan marine sponge Agelas sp. The structures of 1–5 were elucidated on the basis of spectroscopic data and conformational analysis. Mukanadin G (5) has a tricyclic skeleton consisting of a fused tetrahydrobenzaminoimidazole and 2,5-dioxopyrrolidine moieties. Antimicrobial activities of 1–3, and 5 as well as three related known bromopyrrole alkaloids, keramadine (6), tauroacidin A (7), and taurodispacamide A (8) were evaluated.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 62 (5), 499-503, 2014
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204177145344
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- NII Article ID
- 130004053787
- 40020048729
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- NII Book ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC2cnpsVCiug%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 025419749
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- PubMed
- 24789935
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
- KAKEN
- OpenAIRE
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- Abstract License Flag
- Disallowed