Synthesis, Antimicrobial and Cytotoxic Activities of Sulfonamidomethane Linked Heterocycles
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- Swapna Mukkara
- Department of Chemistry, Sri Venkateswara University
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- Premakumari Chokkappagari
- Department of Chemistry, Sri Venkateswara University
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- Reddy Sanapalli Nagi
- Department of Chemistry, Sri Venkateswara University
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- Padmaja Adivireddy
- Department of Chemistry, Sri Venkateswara University
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- Padmavathi Venkatapuram
- Department of Chemistry, Sri Venkateswara University
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- Kondaiah Paturu
- Department of Molecular Reproduction Development and Genetics, Indian Institute of Science
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- Krishna Narra Siva
- Department of Molecular Reproduction Development and Genetics, Indian Institute of Science
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A new class of sulfonamidomethane pyrrolyl–oxadiazoles/thiadiazoles and pyrazolyl–oxadiazoles/thiadiazoles was prepared from arylsulfonylaminoacetic acid hydrazides and E-cinnamic acid. The lead compounds were tested for antimicrobial and cytotoxic activities. The thiadiazole compounds having chloro substituent on the aromatic ring 4c, 8c and 10c exhibited comparable antibacterial activity against Pseudomonas aeruginosa and also antifungal activity against Penicillium chrysogenum. The styryl oxadiazole compound 3c showed appreciable cytotoxic activity on A549 lung carcinoma cells which can be used as a lead compound in the future studies.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 61 (7), 722-730, 2013
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詳細情報 詳細情報について
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- CRID
- 1390001204177542912
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- NII論文ID
- 130003360801
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- NII書誌ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC3sjmsV2jsw%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 024644863
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- PubMed
- 23812397
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可