First Synthesis of Saponarin, 6-C- and 7-O-Di-β-D-glucosylapigenin

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  • First Synthesis of Saponarin, 6-<i>C</i>- and 7-<i>O</i>-Di-<i>β</i>-D-glucosylapigenin

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Saponarin, apigenin 6-C- and 7-O-bis-β-D-glucoside, was synthesized in an overall yield of 37% via 11 steps, which included the C-glycosylation of 2,4-O-dibenzylphloroacetophenone, the introduction of a cinnamoyl residue by aldol condensation, the formation of a flavone by regioselective deprotection, and oxidative ring-closure to the final regioselective deprotection and stereoselective O-glycosylation.

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