Improved Skin Delivery of Voriconazole with a Nanostructured Lipid Carrier-Based Hydrogel Formulation
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- Song Seh Hyon
- College of Pharmacy, Chung-Ang University
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- Lee Kyung Min
- College of Pharmacy, Chung-Ang University
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- Kang Jong Boo
- College of Pharmacy, Chung-Ang University
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- Lee Sang Gon
- College of Pharmacy, Chung-Ang University
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- Kang Myung Joo
- College of Pharmacy, Dankook University
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- Choi Young Wook
- College of Pharmacy, Chung-Ang University
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抄録
In order to develop topical preparations of voriconazole (VRC) for the treatment of mycotic infections of the skin, a nanostructured lipid carrier-based hydrogel (NLC-gel) formulation was developed and its physical characteristics, in vitro skin permeation, and retention profiles were examined. A VRC-loaded NLC dispersion, consisting of Precirol ATO 5, Labrafil 1944 CS, and Tween 80, was prepared by high-pressure homogenization and embedded into Carbopol 940 hydrogel. The lipid nanoparticles in the hydrogel were approximately 210 nm in size, with a spherical shape and zeta potential of −30 mV. In a skin permeation study using a Franz diffusion cell mounted with depilated mouse skin, the NLC-gel was superior to conventional cream and microemulsion-based gel formulations, showing 2.8- and 1.7-fold greater flux values, respectively. In addition, the NLC-gel led to markedly greater accumulation of VRC in deeper skin layers as compared with the reference formulations. In conclusion, the novel topical formulation reported here represents an alternative treatment for skin infections such as candidiasis, with less potential for systemic adverse effects than oral therapy.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 62 (8), 793-798, 2014
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204177569152
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- NII論文ID
- 130004677386
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- NII書誌ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC2cbos1Cruw%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 025609869
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- PubMed
- 25087631
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可