Capsofulvesins A-C, Cholinesterase Inhibitors from Capsosiphon fulvescens

DOI Web Site Web Site PubMed 参考文献14件
  • Fang Zhe
    College of Pharmacy, Catholic University of Daegu
  • Yang Jeong Su
    College of Pharmacy, Catholic University of Daegu
  • Ah Jung Hyun
    Department of Food Science and Human Nutrition, Chonbuk National University
  • Sue Choi Jae
    Division of Food Science and Biotechnology, Pukyong National University
  • Sun Min Byung
    College of Pharmacy, Catholic University of Daegu
  • Hee Woo Mi
    College of Pharmacy, Catholic University of Daegu

書誌事項

タイトル別名
  • Capsofulvesins A–C, Cholinesterase Inhibitors from <i>Capsosiphon fulvescens</i>

この論文をさがす

抄録

Activity-directed isolation of the n-hexane and dichloromethane fractions of Capsosiphon fulvescens resulted in the identification of four new glycolipids (1–3): (2S)-1-O-(6Z,9Z,12Z,15Z-octadecatetraenoyl)-2-O-(4Z,7Z,10Z,13Z-hexadecatetraenoyl)-3-O-β-D-galactopyranosyl glycerol (1, capsofulvesin A), (2S)-l-O-(9Z,12Z,15Z-octadecatrienoyl)-2-O-(10Z,13Z-hexadecadienoyl)-3-O-β-D-galactopyranosyl glycerol (2, capsofulvesin B), (2S)-1-O-(6Z,9Z,12Z,15Z-octadecatetraenoyl)-3-O-β-D-galacatopyranosyl glycerol (3, capsofulvesin C). Compounds 1–6 exhibited acetylcholinesterase (AChE) inhibitory activities with IC50 values ranging from 50.90 to 82.83 µM, whereas 2–6 showed butyrylcholinesterase (BChE) inhibitory activities with IC50 values of 114.75–185.55 µM. Although most of the compounds isolated lacked scavenging activity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and peroxynitrite (ONOO−), compound 8 showed ONOO− scavenging activity with an IC50 value of 26.23 µg/mL.

収録刊行物

参考文献 (14)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ