Asymmetric Reductive Aldol-Type Reaction with Carbonyl Compounds Using Dialkyl Tartrate as a Chiral Ligand
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- Isoda Motoyuki
- Faculty of Pharmaceutical Sciences, Setsunan University
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- Sato Kazuyuki
- Faculty of Pharmaceutical Sciences, Setsunan University
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- Tokura Yoriko
- Faculty of Pharmaceutical Sciences, Setsunan University
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- Tarui Atsushi
- Faculty of Pharmaceutical Sciences, Setsunan University
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- Omote Masaaki
- Faculty of Pharmaceutical Sciences, Setsunan University
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- Ando Akira
- Faculty of Pharmaceutical Sciences, Setsunan University
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Abstract
An asymmetric reductive aldol-type reaction of α,β-unsaturated esters with carbonyl compounds using Rh catalyst and Et2Zn was investigated. A chiral zinc complex from α,β-unsaturated ester was easily generated as the key intermediate from Et2Zn and Wilkinson’s catalyst with diisopropyl L-(+)-tartrate to give a variety of enantioenriched β-hydroxy esters. The reaction was also applied to the intramolecular reductive aldol cyclization.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 62 (10), 956-961, 2014
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204178397440
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- NII Article ID
- 130004693772
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- NII Book ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC2M7ms1Siug%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 025838510
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- PubMed
- 25273054
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed