Synthesis and Evaluation of Novel Cyclopropane Nucleoside as Potential Tube Formation Agents
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- Sakakibara Norikazu
- Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University
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- Igarashi Junsuke
- Department of Cardiovascular Physiology, Faculty of Medicine, Kagawa University
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- Takata Maki
- Department of Pharmaco-Bio-Informatics, Faculty of Medicine, Kagawa University
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- Konishi Ryoji
- Department of Pharmaco-Bio-Informatics, Faculty of Medicine, Kagawa University
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- Kato Yoshihisa
- Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University
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- Tsukamoto Ikuko
- Department of Pharmaco-Bio-Informatics, Faculty of Medicine, Kagawa University
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Description
<p>Five novel nucleoside analogs with mono or bis-hydroxymethylated cyclopropane rings at the N9-position of the 2-chloroadenine moiety (2-chloro-carbocyclic oxetanocin A [COA-Cl] analog) were synthesized and evaluated using human umbilical vein endothelial cells. All the prepared compounds (2a–e) showed good to moderate activity with angiogenic potency. cis-2′-(Hydroxymethyl)cycloprop-1′-yl derivative (2b) at 100 µM had greater angiogenic activity than the other compounds did, with relative tube areas of 2.71±0.45 (mean±standard deviation (S.D.)), which was superior to the potency of COA-Cl (2.30±0.59).</p>
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 65 (5), 504-510, 2017
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204178482944
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- NII Article ID
- 130005631529
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 028137698
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- PubMed
- 28458372
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed