<i>In Vitro</i> Permeation and Skin Retention of α-Mangostin Proniosome
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- Chin Gan Siaw
- Institute of Bioproduct Development, Universiti Teknologi Malaysia
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- Todo Hiroaki
- Faculty of Pharmaceutical Sciences, Josai University
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- Kadhum Wesam Radhi
- Faculty of Pharmaceutical Sciences, Josai University
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- Hamid Mariani Abdul
- Institute of Bioproduct Development, Universiti Teknologi Malaysia
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- Sugibayashi Kenji
- Institute of Bioproduct Development, Universiti Teknologi Malaysia
Bibliographic Information
- Other Title
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- In Vitro Permeation and Skin Retention of α-Mangostin Proniosome
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Abstract
<p>The current investigation evaluated the potential of proniosome as a carrier to enhance skin permeation and skin retention of a highly lipophilic compound, α-mangostin. α-Mangostin proniosomes were prepared using the coacervation phase seperation method. Upon hydration, α-mangostin loaded niosomes were characterized for size, polydispersity index (PDI), entrapment efficiency (EE) and ζ-potential. The in vitro permeation experiments with dermis-split Yucatan Micropig (YMP) skin revealed that proniosomes composed of Spans, soya lecithin and cholesterol were able to enhance the skin permeation of α-mangostin with a factor range from 1.8- to 8.0-fold as compared to the control suspension. Furthermore, incorporation of soya lecithin in the proniosomal formulation significantly enhanced the viable epidermis/dermis (VED) concentration of α-mangostin. All the proniosomal formulations (except for S20L) had significantly (p<0.05) enhanced deposition of α-mangostin in the VED layer with a factor range from 2.5- to 2.9-fold as compared to the control suspension. Since addition of Spans and soya lecithin in water improved the solubility of α-mangostin, this would be related to the enhancement of skin permeation and skin concentration of α-mangostin. The choice of non-ionic surfactant in proniosomes is an important factor governing the skin permeation and skin retention of α-mangostin. These results suggested that proniosomes can be utilized as a carrier for highly lipophilic compound like α-mangostin for topical application.</p>
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 64 (12), 1666-1673, 2016
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204178506624
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- NII Article ID
- 130005170715
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 027752713
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- PubMed
- 27904075
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed