Preparative Separation of High-Purity Dihydroartemisinic Acid from Artemisinin Production Waste by Combined Chromatography
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- Liu Shuoqian
- Department of Tea Science, College of Horticulture and Hardening, Hunan Agricultural University National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals
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- Ferreira Jorge Freire da Silva
- U.S. Salinity Laboratory, United States Department of Agriculture Agricultural Research Service
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- Tian Dongming
- National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals
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- Tang Yuwei
- Department of Tea Science, College of Horticulture and Hardening, Hunan Agricultural University
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- Liu Liping
- Department of Tea Science, College of Horticulture and Hardening, Hunan Agricultural University
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- Yang Wei
- National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals
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- Liu Zhonghua
- Department of Tea Science, College of Horticulture and Hardening, Hunan Agricultural University National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals
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- Tian Na
- Department of Tea Science, College of Horticulture and Hardening, Hunan Agricultural University
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Abstract
<p>In order to make full use of artemisinin production waste and thus to reduce the production cost of artemisinin, we developed an efficient and scalable method to isolate high-purity dihydroartemisinic acid from artemisinin production waste by combining anion-exchange resin with silica-gel column chromatography. The adsorption and desorption characteristics of dihydroartemisinic acid on 10 types of anion-exchange resin were investigated, and the results showed that the 717 anion-exchange resin exhibited the highest capacity of adsorption and desorption to dihydroartemisinic acid. Adsorption isotherms were established for the 717 anion-exchange resin and they fitted well with both Langmuir and Freundlich model. Dynamic adsorption and desorption properties of 717 anion-exchange resin were characterized to optimize the chromatographic conditions. Subsequently, the silica-gel column chromatography was performed and dihydroartemisinic acid with a purity of up to 98% (w/w) was obtained. Finally, the scale-up experiments validated the preparative separation of high-purity dihydroartemisinic acid from industrial waste developed in the present work. This work presented for the first time an isolation of dihydroartemisinic acid with a purity of 98% from Artemisia annua (A. annua) by-product, which adds more value to this crop and has the potential to lower the prices of anti-malarial drugs.</p>
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 66 (3), 319-326, 2018
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390001204178606976
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- NII Article ID
- 130006407042
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 028854090
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- PubMed
- 29311435
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed