Improved Synthetic Route to Methyl 1-Fluoroindan-1-carboxylate (FICA Me Ester) and 4-Methyl Derivatives

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Abstract

An improved synthetic route has been developed for the preparation of methyl 1-fluoroindan-1-carboxylate (FICA Me ester) from 1-indanone. Methyl 4-methyl-1-fluoroindan-1-carboxylate (4-Me-FICA Me ester) was also prepared following the same procedure.

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