Synthesis of 4'-Thionucleosides as Antitumor and Antiviral Agents

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  • Yoshimura Yuichi
    Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University
  • Saito Yukako
    Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University
  • Natori Yoshihiro
    Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University
  • Wakamatsu Hideaki
    Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University

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  • Synthesis of 4′-Thionucleosides as Antitumor and Antiviral Agents

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<p>Many attempts have been made to synthesize structurally novel nucleoside derivatives in order to identify effective compounds for the treatment of tumors and virus-caused disease. At our laboratories, as part of our efforts to synthesize 4′-thionucleosides, we have identified and characterized biologically active nucleosides. During the course of our synthetic study, we developed the Pummerer-type thioglycosylation reaction. As a result, we synthesized a potent antineoplastic nucleoside, 1-(2-deoxy-2-fluoro-β-D-4-thio-arabino-furanosyl)cytosine (4′-thioFAC), and several novel 4′-thionucleosides that possess antiherpes virus activities.</p>

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