An Efficient Green Multi-Component Reaction Strategy for the Synthesis of Highly Functionalised Pyridines and Evaluation of Their Antibacterial Activities
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- Srinivasula Reddy Lakkireddy
- Department of Chemistry, Sri Venkateswara University Dr. Reddy’s Laboratories Limited
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- Ram Reddy Tirumalareddy
- Dr. Reddy’s Laboratories Limited
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- Mohan Reddy Bodireddy
- Department of Chemistry, School of Physical Sciences, Yogi Vemana University
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- Mahesh Avula
- Dr. Reddy’s Laboratories Limited
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- Lingappa Yeramanchi
- Department of Chemistry, Sri Venkateswara University
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- Gangi Reddy Nallagondu Chinna
- Department of Chemistry, School of Physical Sciences, Yogi Vemana University
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An efficient green multi-component reaction (MCR) method has been developed for the synthesis of 2-amino-4-aryl/heteroaryl-6-(pyridin-2-ylthio)pyridine-3,5-dicarbonitrile(s) via a 3-component reaction of aryl aldehyde(s), malononitrile and 2-mercaptopyridine in the presence of K2CO3 under solvent free reaction conditions (SFRC) using grinding technique at room temperature in a single step. The advantages of the present protocol is operationally simple, environmentally benign, solvent-free reaction conditions (SFRC), simple work up, excellent isolated yields of desired products and viable method for large scale applications in pharmaceutical industry. Interestingly, the synthesized compounds showed moderate to excellent antibacterial activities against Gram-positive and Gram-negative bacterial strains.
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 61 (11), 1114-1120, 2013
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204179011584
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- NII論文ID
- 130003381776
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- NII書誌ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC2c7ivFyjtA%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 024957113
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- PubMed
- 24189299
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可