Rubescins A, B and C : New Havanensin Type Limonoids from Root Bark of Trichilia rubescens (Meliaceae)
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- Tsamo Tontsa Armelle
- Department of Organic Chemistry, University of Yaounde I
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- Mkounga Pierre
- Department of Organic Chemistry, University of Yaounde I
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- Njayou Fréderic Nico
- Department of Biochemistry, University of Yaounde I
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- Manautou José
- Department of Pharmaceutical Sciences, University of Connecticut
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- Kirk Marat
- Department of Chemistry, University of Manitoba
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- Hultin Philip Gregory
- Department of Chemistry, University of Manitoba
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- Nkengfack Augustin Ephrem
- Department of Organic Chemistry, University of Yaounde I
書誌事項
- タイトル別名
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- Rubescins A, B and C: New Havanensin Type Limonoids from Root Bark of <i>Trichilia rubescens</i> (Meliaceae)
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抄録
Three new limonoids, rubescins A–C (1–3), and three known compounds including, havanensin type limonoid TS3 (4), β-sitosterol, and stigmasterol were isolated from the root bark of Trichilia rubescens. Their structures were elucidated by means of extensive spectroscopic analyses, particularly one dimensional (1D)- and 2D-NMR techniques in conjunction with mass spectrometry. Rubescins A–C (1–3) and limonoid TS3 (4) were evaluated for their protective effects against oxidative stress induced in HC-04 cells by H2O2. Compound (1) showed strong inhibitory effects on lactase dehydrogenase (LDH) leakage, being as active (IC50 value of 0.0026 µM) as the positive control quercetin (IC50 value of 0.0030 µM).
収録刊行物
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- ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ
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ＣＨＥＭＩＣＡＬ ＆ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ ＢＵＬＬＥＴＩＮ 61 (11), 1178-1183, 2013
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204179020160
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- NII論文ID
- 130003381781
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- NII書誌ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC2c7ivFyisA%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 024957238
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- PubMed
- 24189305
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可