Medicinal Flowers (33) Anti-hyperlipidemic and Anti-hyperglycemic Effects of Chakasaponins Ⅰ-Ⅲ and Structure of Chakasaponin Ⅳ from Flower Buds of Chinese Tea Plant (Camellia sinensis)
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- Matsuda Hisashi
- Kyoto Pharmaceutical University
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- Hamao Makoto
- Kyoto Pharmaceutical University
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- Nakamura Seikou
- Kyoto Pharmaceutical University
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- Kon’i Haruka
- Kyoto Pharmaceutical University
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- Murata Megumi
- Kyoto Pharmaceutical University
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- Yoshikawa Masayuki
- Kyoto Pharmaceutical University
書誌事項
- タイトル別名
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- Medicinal Flowers. XXXIII. Anti-hyperlipidemic and Anti-hyperglycemic Effects of Chakasaponins I–III and Structure of Chakasaponin IV from Flower Buds of Chinese Tea Plant (<i>Camellia sinensis</i>)
- Medicinal flowers. XXXIII. Anti-hyperlipidemic and anti-hyperglycemic effects of chakasaponins I—III and structures of chakasaponin IV from flower buds of Chinese tea plant (Camellia sinensis)
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抄録
Effects of principal saponins, chakasaponins I–III, from the flower buds of Camellia sinensis cultivated in Fujian province, China on plasma triglyceride (TG) and glucose levels in olive oil or sucrose-loaded mice were examined. Chakasaponins I–III at 50 and 100 mg/kg significantly inhibited increases in plasma TG and glucose levels. Furthermore, they prevented gastric emptying, suggesting that the former inhibitory effect is partly dependent on the inhibition of gastric emptying. In addition, the chemical structure of a new acylated oleanane-type triterpene oligoglycoside, chakasaponin IV, was elucidated on the basis of chemical and physicochemical evidence.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 60 (5), 674-680, 2012
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204179097728
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- NII論文ID
- 130001852466
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- NII書誌ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC38jgvFaltA%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 023593539
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- PubMed
- 22689407
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可