The Antimicrobial Activities of Phenylbutyrates against Helicobacter pylori
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- Lo Chung-Yi
- Graduate Institute of Bioresource, National Pingtung University of Science and Technology
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- Cheng Hsueh-Ling
- Department of Biological Science & Technology, National Pingtung University of Science and Technology
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- Hsu Jue-Liang
- Department of Biological Science & Technology, National Pingtung University of Science and Technology
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- Liao Ming-Hui
- Department of Veterinary Medicine, National Pingtung University of Science and Technology
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- Yen Rong-Lang
- Antromed Biotech. Inc.
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- Chen Yo-Chia
- Graduate Institute of Bioresource, National Pingtung University of Science and Technology Department of Biological Science & Technology, National Pingtung University of Science and Technology
書誌事項
- タイトル別名
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- The Antimicrobial Activities of Phenylbutyrates against <i>Helicobacter pylori</i>
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説明
Three phenyl derivatives of butyrate, 2-phenylbutyrate (2-PB), 3-phenylbutyrate (3-PB) and 4-phenylbutyrate (4-PB), were evaluated in terms of their antibacterial and cytotoxic activities. Our results indicated that PBs demonstrated specific inhibitory activity against Helicobacter pylori and Escherichia coli but did not influence the growth of Bifidobacterium bifidium and Lactobacillus reuteri. PBs also exhibited synergistic effects on H. pylori ATCC 43504 especially at pH 5.5. In the protein expression profiles in H. pylori treated by phenylbutyrates, we also found that three protein spots identified as oxidative stress-related proteins were significantly up-regulated, confirming the response of H. pylori when exposed to PBs. Due to their antibacterial activities and low or slight cytotoxicities, PBs are potential candidates for the treatment of H. pylori infection. This is the first study to discover the antibiotic effects of 2-PB, 3-PB and 4-PB (Buphenyl).
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 61 (6), 604-610, 2013
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204179311616
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- NII論文ID
- 130003360783
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- NII書誌ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC3snovV2ltg%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 024523868
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- PubMed
- 23727774
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可