The Antimicrobial Activities of Phenylbutyrates against Helicobacter pylori

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  • Lo Chung-Yi
    Graduate Institute of Bioresource, National Pingtung University of Science and Technology
  • Cheng Hsueh-Ling
    Department of Biological Science & Technology, National Pingtung University of Science and Technology
  • Hsu Jue-Liang
    Department of Biological Science & Technology, National Pingtung University of Science and Technology
  • Liao Ming-Hui
    Department of Veterinary Medicine, National Pingtung University of Science and Technology
  • Yen Rong-Lang
    Antromed Biotech. Inc.
  • Chen Yo-Chia
    Graduate Institute of Bioresource, National Pingtung University of Science and Technology Department of Biological Science & Technology, National Pingtung University of Science and Technology

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  • The Antimicrobial Activities of Phenylbutyrates against <i>Helicobacter pylori</i>

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Three phenyl derivatives of butyrate, 2-phenylbutyrate (2-PB), 3-phenylbutyrate (3-PB) and 4-phenylbutyrate (4-PB), were evaluated in terms of their antibacterial and cytotoxic activities. Our results indicated that PBs demonstrated specific inhibitory activity against Helicobacter pylori and Escherichia coli but did not influence the growth of Bifidobacterium bifidium and Lactobacillus reuteri. PBs also exhibited synergistic effects on H. pylori ATCC 43504 especially at pH 5.5. In the protein expression profiles in H. pylori treated by phenylbutyrates, we also found that three protein spots identified as oxidative stress-related proteins were significantly up-regulated, confirming the response of H. pylori when exposed to PBs. Due to their antibacterial activities and low or slight cytotoxicities, PBs are potential candidates for the treatment of H. pylori infection. This is the first study to discover the antibiotic effects of 2-PB, 3-PB and 4-PB (Buphenyl).

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