Production of an isomeric state of 90Y by fast neutrons for nuclear diagnostics

  • Nagai Yasuki
    Nuclear Science and Engineering Directorate, Japan Atomic Energy Agency Research Center for Nuclear Physics, Osaka University
  • Iwamoto Osamu
    Nuclear Science and Engineering Directorate, Japan Atomic Energy Agency
  • Iwamoto Nobuyuki
    Nuclear Science and Engineering Directorate, Japan Atomic Energy Agency
  • Kin Tadahiro
    Nuclear Science and Engineering Directorate, Japan Atomic Energy Agency
  • Segawa Mariko
    Nuclear Science and Engineering Directorate, Japan Atomic Energy Agency
  • Hatsukawa Yuichi
    Quantum Beam Science Directorate, Japan Atomic Energy Agency
  • Harada Hideo
    Nuclear Science and Engineering Directorate, Japan Atomic Energy Agency

書誌事項

タイトル別名
  • Production of an Isomeric State of <SUP>90</SUP>Y by Fast Neutrons for Nuclear Diagnostics

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抄録

90gY radiopharmaceuticals for cancer therapy have been used together with 111In radiopharmaceuticals for diagnostics, since a daughter nucleus of 90Sr, the ground state of 90Y, 90gY, is a pure β-ray emitting nucleus with no γ-ray emissions, providing no practical way for imaging. We have noted that the 682 keV isomeric state of 90Y, 90mY, with a half-life of 3.2 h as well as 90gY can be populated significantly by 90Zr(n,p)90Y and 93Nb(n,α)90Y at a neutron energy of 14 MeV. On the basis of the result, we have proposed a new method to use 90Y radiopharmaceuticals containing 90mY for diagnostics and 90gY for therapy, since the isomeric state decays to the ground state of 90Y by emitting 480 and 203 keV γ-rays, appropriate energies for imaging. 90Y radiopharmaceuticals containing 90mY could solve long-standing problems associated with the use of 90gY together with 111In for imaging.

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