Immunochemical properties of abnormal IgG2 molecule, not reacted by anti-.GAMMA.CH2 domain antibody in a patient with multiple myeloma.
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- Fujita Kiyotaka
- Department of Clinical Laboratory, Hanazono Hospital
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- Sakurabayashi Ikunosuke
- 自治医科大学大宮医療センター検査部
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- Kawai Tadashi
- 自治医科大学臨床病理学教室
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- Kusanagi Mutsuko
- Department of Clinical Laboratory, Hanazono Hospital
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- Teramura Yoshimi
- 花園病院内科
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- Yamada Hironori
- 名古屋掖済会病院内科
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- Takeyama Hideo
- 名古屋掖済会病院内科
Bibliographic Information
- Other Title
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- 多発性骨髄腫例に認められたＣＨ２ドメインの欠損が考えられる異常分子ＩｇＧ２の免疫化学的特性
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Abstract
Abnormal IgG2 molecule, not reacted by anti-γCH2 domain antibody were found in a patient with typical multiple myeloma. The IgG molecules were found to have a molecular weight of 94, 000 and 99, 000 daltons and were composed of one γ2 chain of about 44, 000 daltons and two light chains of 28, 000 daltons. We suggest that the γCH2 domain of the patient's M-protein was defected, since the molecular weight for heavy chain of IgG was about 6, 000 daltons smaller than that of the heavy chain from normal IgG, and the patient's M-protein was not reacted by anti-γCH2 domain antibody.
Journal
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- SEIBUTSU BUTSURI KAGAKU
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SEIBUTSU BUTSURI KAGAKU 34 (1), 19-23, 1990
Japanese Electrophoresis Society
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Details 詳細情報について
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- CRID
- 1390001204200951296
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- NII Article ID
- 130003433464
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- ISSN
- 13499785
- 00319082
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed