書誌事項
- タイトル別名
-
- Analysis of lipoprotein particles in dyslipidemia: Estimation of lipoprotein particle size and its clinical application.
- リポ タンパクシツ ノ ブンセキ ト ショウレイ LDL サイズ ノ ソクテイホウ オヨビ small dense LDL ノ リンショウテキ イギ
- Estimation of lipoprotein particle size and its clinical application
- LDLサイズの測定法および small, dense LDL の臨床的意義
この論文をさがす
抄録
Increased frequency of small, dense LDL is associated with the risk of coronary heart disease (CHD). Possible mechanisms include increased susceptibility of small, dense LDL to oxidation and its high affinity for LDL-receptor-independent cell surface binding sites. Although more than 30% of adult men in USA has been reported to have small, dense LDL, only 5.4% of young Japanese men had small, dense LDL. However, more than 70% of Japanese subjects with CHD had small, dense LDL, indicating a clinical importance of LDL size in the development of CHD in Japan. Furthermore, almost half of obese women (BMI>35kg/m2) had small, dense LDL. Our previous observation revealed that type 2 diabetics had smaller LDL even if they were apparently normolipidemic. There was also a close relationship between LDL size and plasma triglyceride even in the population with normotriglyceridemia, which may suggest that the plasma triglyceride is“the lower the better”from the stand point of LDL size. Finally, weight reduction of obese women by strict diet control, treatment of diabetics by acarbose or troglitazone and treatment of hyperlipidemia by a new statins, fluvastatin, were all successful in increasing LDL size associated with decreased plasma triglyceride.
収録刊行物
-
- 生物物理化学
-
生物物理化学 45 (2), 159-164, 2001
日本電気泳動学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001204201043712
-
- NII論文ID
- 130003607256
- 10012788226
-
- NII書誌ID
- AN00129729
-
- ISSN
- 13499785
- 00319082
-
- NDL書誌ID
- 5807841
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可
