Lp(a)測定の標準化と疾患における意義

  • 久保野 勝男
    株式会社エスアールエル研究検査部 杏林大学医学部生化学第二
  • 櫻林 郁之介
    自治医科大学大宮医療センター総合医学I, 検査部

書誌事項

タイトル別名
  • Standardization for Lp(a) measurement and clinical investigation.
  • Lp a ソクテイ ノ ヒョウジュンカ ト シッカン ニ オケル イギ

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説明

In order to standardize the lipoprotein(a) [Lp(a)] measurement, the International Federation of Clinical Chemistry Working Group on Lp(a) (IFCC Lp(a) WG) and the Japan Society of Clinical Pathology Working Group on Lp(a) Standardization were established in 1995, 1994, respectively. In the activities on IFCC Lp(a) WG, eight proposed reference materials (PRM) were compared for their analytical performance, commutable properties, method harmonization, and selected PRM-2B (Behring) as the most suitable PRM. In the next phase of the IFCC Lp(a) WG, a value transfer protocol will be used to transfer a Lp(a) value from the PRM-2 for Lp(a) to manufactures' master calibrators, and WG will submit the results to WHO. On the other hand, it is recommended that the Lp(a) protein concentration should be expressed in molar units for more accurate Lp(a) measurement. So it will be expected that new clinical estimation is investigated.

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