World of antisense RNA.

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  • Funato Tadao
    Department of Laboratory Science, School of Health Science, Faculty of Medicines, Kyoto University
  • Takeda Mayu
    Department of Laboratory Science, School of Health Science, Faculty of Medicines, Kyoto University
  • Yoshida Mami
    Department of Laboratory Science, School of Health Science, Faculty of Medicines, Kyoto University

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  • アンチセンスＲＮＡの世界
  • アンチセンス RNA ノ セカイ

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Abstract

In many experimental systems, antisense nucleic acids of various compositions, including antisense oligodeoxynucleotides, ribozymes, and DNAzymes, have been shown to perturb gene expression in a sequence specific manner. Nevertheless, we have employed need to be optimized with regard to intracellular delivery, targeting, chemical composition, and efficiency of mRNA destruction. These sequence-specific inhibitors of gene expression may have therapeutic potential in the treatment of a wide range of diseases. We have addressed these critical issues lead to the development of practical and effective nucleic acid drugs within this review.<br>

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