慢性肝疾患患者血清コリンエステラーゼアイソザイムのレクチン電気泳動による解析

DOI

書誌事項

タイトル別名
  • Analysis of serum cholinesterase isozymes in patients with chronic liver diseases by use of lectincontaining agarose gel electrophoresis.

抄録

We investigated whether or not liver cirrhosis (LC) can be discriminated from chronic hepatitis (CH) by analysis of serum cholinesterase (ChE) isozymes using affinity electrophoresis with concanavalin A (Con A), wheat germ agglutinin (WGA), lens culinaris agglutinin (LCA) or ricinus communis agglutinin I (RCA I). On Con A-containing agarose gel electrophoresis, one of three ChE isozymes disappeared in 50% (15/30) of cirrhotic patients. But only one of 20 patients with CH had the same abnormality. WGA-containing agarose gel electrophoresis revealed that normal controls and patients with CH had four ChE isozymes. However, approximately 63% (20/32) of cirrhotic patients lacked one of the four ChE isozymes. When these two affinity electrophoresis were used in combination, 73% (22/30) of cirrhotic patients had isozymic alteration of their serum ChE on either Con A- or WGA-containing agarose gel electrophoresis or both. The data obtained by use of LCA or RCA I was less contributable.

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詳細情報 詳細情報について

  • CRID
    1390001204202694400
  • NII論文ID
    130003606904
  • DOI
    10.2198/sbk.35.189
  • ISSN
    13499785
    00319082
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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