Study on qualitative abnormality of LDL fraction by simultaneous determination of serum cholesterol and triglyceride fractions.

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  • Ohi Kinue
    Department of Laboratory Medicine, Mie University School of Medicine
  • Sakurai Yuko
    三重大学医学部附属病院中央検査部
  • Nobori Tsutomu
    Department of Laboratory Medicine, Mie University School of Medicine

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  • 血清コレステロール分画・トリグリセライド分画同時測定によるＬＤＬ分画質的異常の検討
  • ケッセイ コレステロール ブンカク トリグリセライド ブンカク ドウジ ソクテイ ニ ヨル LDL ブンカク シツテキ イジョウ ノ ケントウ

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Abstract

LDL fraction was qualitatively analyzed by simultaneous determination of serum cholesterol and triglyceride (TG) by agarose gel electrophoresis. Modified low density lipoprotein (LDL) showing faster electrophoretic mobility was easily distinguished from native LDL. Modification frequency is determined by a relative change of the mobility shift to the anode. Modification frequency greater 8 is defined as positive modified LDL. The modified LDL was found in 46.9% of 131 patients with higher level of TG and 4.1% of 147 patients with normal TG level. 73.4% of 53 patients with modified LDL had the level of TG≥300mg/dl. These data suggested that modified LDL was mostly consisted of small dense LDL with a high level of TG. However, the level of TG was decreased faster than that of modified LDL.

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