Acute oral toxicities of natural food additives.

DOI
  • NODA Tsutomu
    Department of Hygienic Chemistry, Osaka City Institute of Public Health and Environmental Sciences
  • MORITA Shigeru
    Department of Hygienic Chemistry, Osaka City Institute of Public Health and Environmental Sciences
  • OHGAKI Sumiko
    Department of Hygienic Chemistry, Osaka City Institute of Public Health and Environmental Sciences
  • SHIMIZU Mitsuru
    Department of Hygienic Chemistry, Osaka City Institute of Public Health and Environmental Sciences
  • YAMANO Tetsuo
    Department of Hygienic Chemistry, Osaka City Institute of Public Health and Environmental Sciences
  • YAMADA Akio
    Department of Hygienic Chemistry, Osaka City Institute of Public Health and Environmental Sciences

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Other Title
  • 天然食品添加物の経口投与による急性毒性試験

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Acute oral toxicity tests, in rats and mice, were carried out for 42 natural food additives used in Japan-24 food colors, 7 thickening agents, 5 flavouring agents, 4 food enzymes, 1 fruit glaze and 1 bitter ing agent. Deaths of animals were caused only by the administration of 4 additives, anis oil, pimenta oil, orange oil and wood vinegar. Liver injury was observed in rats treated with gardenia yellow, 7 days after administration. No harmful effects occurred in animals given the other natural food additives.

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