Effect of intracellular localization of cyclin D1 on the proliferation in oral squamous cell carcinoma

DOI Web Site 15 References
  • Watanabe Masahiro
    Graduate School of Dentistry (Second Department of Oral and Maxillofacial Surgery), Osaka Dental University
  • Ohnishi Yuichi
    Second Department of Oral and Maxillofacial Surgery, Osaka Dental University
  • Fujii Tomoko
    Graduate School of Dentistry (Second Department of Oral and Maxillofacial Surgery), Osaka Dental University
  • Minamino Yuki
    Graduate School of Dentistry (Second Department of Oral and Maxillofacial Surgery), Osaka Dental University
  • Ugaki Yoshihide
    Graduate School of Dentistry (Second Department of Oral and Maxillofacial Surgery), Osaka Dental University
  • Inoue Hiroshi
    Second Department of Oral and Maxillofacial Surgery, Osaka Dental University
  • Dateoka Suguru
    Second Department of Oral and Maxillofacial Surgery, Osaka Dental University
  • Sugitatsu Mitsuchika
    Department of Dentistry and Maxillofacial Surgery, Osaka Red Cross Hospital
  • Nakajima Masahiro
    Second Department of Oral and Maxillofacial Surgery, Osaka Dental University
  • Kakudo Kenji
    Second Department of Oral and Maxillofacial Surgery, Osaka Dental University

Bibliographic Information

Other Title
  • 口腔扁平上皮癌におけるCyclin D1の細胞内局在と増殖能との関連
  • コウコウ ヘンペイ ジョウヒガン ニ オケル Cyclin D1 ノ サイボウ ナイキョクザイ ト ゾウショクノウ ト ノ カンレン

Search this article

Abstract

Cyclin D1 governs phosphorylation of the retinoblastoma protein (RB) and controls the G1 phase of cell cycles. This gene may well be necessary for cancer development. We investigated the expression and localization of cyclin D1 protein in HSC 4, an oral squamous cell carcinoma cell line. The results showed that cyclin D1 protein is located in the nuclei of proliferating cells in HSC 4. Furthermore, cyclin D1 protein is decreased and translocated from the nucleium to the cytoplasm under dense culture conditions. In anchorage-independent growth, HSC 4 stopped proliferation and cyclin D1 protein was localized in the cytoplasm. These findings suggest that cyclin D1 protein is related to the proliferation of cells and regulation of the cell cycle in oral squamous cell carcinoma.

Journal

  • Shikaigaku

    Shikaigaku 75 (2), 70-75, 2012

    Osaka Odontological Society

References(15)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top