Supraacute changes in the somatosensory evoked potential following transient forebrain ischemia in gerbils

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  • 一過性前脳虚血後の体性感覚誘発電位の超急性変化について

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Abstract

We did on electrophysiological study to examine supraacute changes in the somatosensory evoked potential (SEP) of gerbils following transient forebrain ischemia and reperfusion. The bilateral carotid arteries were ligated for 12. Fig. 1 shows six gerbils classified as the ischemia group. The control groups recieved a sham operation. The regional cortical cerebral blood flow (r-CBF) and brain temperature were monitored for both groups. SEP devices were attached to the animals and baseline measurements were obtained. Transient forebrain ischemia was achieved in the ischemia group by ligation of the carotid arteries for 5 minutes. R-CBF and SEP were measured in both groups for 30 minutes after either reperfusion or the sham operation. R-CBF decreased 30minutes after the sham operation in the controls. In the ischemia group, r-CBF increased after reperfusion for hyperemia. While SEP latency was stable in the controls during the measurements, it disappeared after reperfusion in the ischemia group. We concluded that it is difficult to evaluate neurological dysfunction in gerbils following transient forebrain ischemia and reperfusion using SEP. A total examination may be needed that includes other neurological factors, such as glutamate, and other hemological factors.

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  • Shikaigaku

    Shikaigaku 67 (2), 201-204, 2004

    Osaka Odontological Society

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