Ultrastructure of Candida albicans in dimorphic transition.

DOI Open Access
  • Kanbe Toshio
    Laboratory of Medical Mycology, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine
  • Shimizu Katsumi
    Laboratory of Medical Mycology, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine
  • Tanaka Kenji
    Laboratory of Medical Mycology, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine

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  • Ｃａｎｄｉｄａ　ａｌｂｉｃａｎｓの二形性変換と微細構造

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Ultrastructure of the cell wall and cytoplasm, and behavior of cytoskeletons were studied in the germ tube formation of the dimorphic yeast Candida albicans.<br>Mannan detected by Con A-HRP-DAB method was distributed in three layers of the cell wall, and no difference was found in localization between the two growth phases. Alkali-acid insoluble glucan consisted of a meshwork of fibrillar materials, and was more developed in the yeast phase cell than in the germ tube cells. A bundle of glucan fibrils circumscribed the mother-bud neck of the budding cells. Chitin granules were found predominantly in the germ tube but rarely in the mother cell.<br>A number of cytoplasmic vesicles were observed in the tip of the budding cell as well as in the germ tube apex. The germ tube showed structural differentiation from the apex to the basipetal zone similar to that seen in the filamentous fungi showing hyphal tip growth.<br>Cytoplasmic microtubules were more prominent in germ tube cells than in budding cells. Some of them extended to the germ tube apex. Intracellular actin granules were localized in the budding site or the germ tube apex, which suggested that actin may play an important role in the cell wall synthesis.

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