が口そうカンジダの産生する糖たんぱく毒素に関する研究 II 毒素および菌体マンナンのLimulus amoebocyte lysate(LAL)のゲル化活性
書誌事項
- タイトル別名
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- Studies on Glycoprotein Toxins Produced by a <i>Candida albicans</i> Strain
- 第2報 毒素および菌体マンナンの<i>Limulus</i> amoebocyte lysate (LAL) のゲル化活性
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One of the C. albicans GP toxins (Fr II-2) was demonstrated to possess a Limulus amoebocyte lysate (LAL)-gelling activity. The mannan moiety of the toxin was considered to contribute in exhibiting the activity. Purified mannans from C. albicans and Saccharomyces cerevisiae also showed a LAL-gelling activity; the activity of the latter was inactivated by treatment with Oerskovia mannanase. The both mannans manifested a lethal activity for mice when upon i. v. injected, being lower than the GP toxin. The GP toxin showed a pyrogenic activity, while C. albicans mannan did not. The GP toxin, mannan and C. albicans formol-killed cells were found to shorten plasma coagulation time. These results suggest that C. albicans GP toxin are classified into a category of fungal endotoxins.
収録刊行物
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- 真菌と真菌症
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真菌と真菌症 21 (4), 274-285, 1980
日本医真菌学会
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詳細情報 詳細情報について
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- CRID
- 1390001204212655744
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- NII論文ID
- 130004809928
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- ISSN
- 18846971
- 05830516
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- 抄録ライセンスフラグ
- 使用不可