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A case of chromomycosis successfully treated with topical hyperthermia.
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- Takahashi Yasuhide
- Department of Dermatology, Yokohama City University School of Medicine
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- Kurosawa Tsutae
- Department of Dermatology, Yokohama City University School of Medicine
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- Mohri Shinobu
- Department of Dermatology, Yokohama City University School of Medicine
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- Iemoto Gaijiroh
- Department of Dermatology, Yokohama City University School of Medicine
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- Iiyoshi Eriko
- Department of Dermatology, Yokohama City University School of Medicine
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- Nakajima Hiroshi
- Department of Dermatology, Yokohama City University School of Medicine
Bibliographic Information
- Other Title
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- 局所温熱療法により治ゆしたクロモミコーシスの１例 局所温熱療法による組織学的変化の経時的検討
Description
We report a 68-year-old man with chromomycosis successfully treated with topical hyperthermia. He had been suffering for ten years from a skin lesion on his upper right arm. When he visited our clinic, the skin lesion was an annular erythematous plaque with scales, measuring 7×11cm2. A potassium hydroxide preparation of the scales revealed several sclerotic cells. Fonecaea pedrosoi was isolated from both the scales and biopsy specimen. The patient was treated with topical hyperthermia using a pocket warmer for 12 hours a day. During the treatment, the temperature of the dermis was maintained at 39°C. The lesion healed in about five weeks. The ioslated fungus did not grow at either 39°C or 41°C. However, when cultured for 12 hours at 39°C and 12 hours at room temperature everyday, it grew to 80% of the size of a culture at room temperature. A histopathological study showed that the number of neutrophils in the dermis decreased immediately after the therapy. The lymphocytes, plasma cells, histiocytes, and foreign body giant cells gradually increased in number. These results suggest that the efficacy of hyperthermia in chromomycosis is not only its direct effect on fungi, but the activation of cell-mediated immunity, consequent enhancement of granulomatous reaction, and the activation of humoral immunity.
Journal
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- Japanese Journal of Medical Mycology
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Japanese Journal of Medical Mycology 30 (3), 191-201, 1989
The Japanese Society for Medical Mycology
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Details 詳細情報について
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- CRID
- 1390001204212915968
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- NII Article ID
- 130003671427
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- ISSN
- 18846971
- 05830516
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed
