A CASE OF COWDEN'S DISEASE ACCOMPANIED WITH RECTAL CARCINOMA IN ADENOMA

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  • 直腸腺腫内癌を合併したＣｏｗｄｅｎ病の１例

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Abstract

We reported a case of Cowden's disease in a 42-year-old woman who visited our hospital for further examination of upper gastrointestinal tract. She had undergone the operation for left breast cancer in the 34-year-old and myoma of uterus in the 37-year-old, respectively. Endoscopic examination revealed multiple small polyps in the esophagus, the stomach and the colon. The biopsy specimen from these polyps showed glycogenic acanthosis in the esophagus and hyperplasia in the stomach. Endoscopic polypectomy of the rectal polyp was performed and its histological findings demonstrated carcinoma in adenoma. She had small keratotic papulosis on the face and extremities, papillomatous lesions in the oral cavity. These findings were compatible to make diagnosis as Cowden's disease.

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