EXPERIMENTAL STUDY INTRALUMINAL MUCOSAL BLOOD FLOW AS THE ETIOLOGICAL FACTOR OF ISCHEMIC COLITIS

NOMURA Koji, FUJITA Kiyoshi, HARIMA Takashi, UCHIDA Yoshihito, KAWANO Hiroshi, FUJIKAWA Yoshinori, MIYAHARA Taeko, TAKEMOTO Tadayoshi, WATANABE Masatoshi, KAWASHIMA Masao

doi:10.11280/gee1973b.25.531

The purpose of this study was to investigate an association between intraluminal pressure and colonic blood flow, which might be involved strongly as the genesis of ischemic colitis. Using rabbit, we studied on the blood flow in the segmented large intestine by ligation after insertion of intraluminal catheter into the colon. The mucosal blood flow in both sites of taenia and non-taenia coli was measured simulataneously while segmented intestine was inflated following stepwise increments of intraluminal pressures of 0, 10, 30 mmHg and was deflated thereafter. As the results, the changes of mucosal blood flow measured in several condition inflated with intraluminal pressures of 0, 10, 30 mmHg and following decompression were as follows ; (1) at the site of taenia coli : 97.5, 105.9, 10.3, 99.5 ml/min/100 g respectively, and (2) at the site of non-taenia coli : 83.4, 94.8, 32.9, 89.1 ml/min/100 g respectively. With the pressure of 30 mmHg, the blood flow in both sites was reduced, but especially the reduction at the site of taenia coli was markedly. Colonic mucosal blood flow was clearly influenced by the change of intraluminal pressure, showing that particularly the blood flow of the site of taenia coli decreased much more by the high pressure, this may be one of the reasons why longitudinal ulcer is seen frequently at the site of taenia coli. In conclusion, it is stronly considered that the high intraluminal pressure might be involved into the etiological factor of ischemic colitis.

EXPERIMENTAL STUDY INTRALUMINAL MUCOSAL BLOOD FLOW AS THE ETIOLOGICAL FACTOR OF ISCHEMIC COLITIS

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