DIAGNOSIS AND TREATMENT OF EOSINOPHILIC ESOPHAGITIS
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- KINOSHITA Yoshikazu
- Department of Gastroenterology and Hepatology, Shimane University School of Medicine
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- ISHIHARA Shunji
- Department of Gastroenterology and Hepatology, Shimane University School of Medicine
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- AMANO Yuji
- Division of Endoscopy, Shimane University Hospital
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- FUJISHIRO Hirofumi
- Division of Endoscopy, Shimane Prefectural Central Hospital
Bibliographic Information
- Other Title
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- 好酸球性食道炎の診断と治療
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Abstract
Eosinophilic esophagitis is a rare type of esophageal disease that features dense intra-epithelial infiltration by eosinophils, which is caused by an allergic reaction to food or aeroallergens. Chronic eosinophil-related inflammation causes edema and fibrosis in the esophageal submucosal layer, while abnormal esophageal motor activity and fibrosis-related esophageal stenosis result in unpleasant symptoms including dysphagia and food impaction. In an endoscopic study of affected patients, longitudinal furrows, whitish stipple-like exudates, and multiple focal strictures were often found. For establishment of the diagnosis, dense infiltration of eosinophils (15-30 eosinophils/HPF) should be identified in an esophageal mucosal biopsy specimen. Local administration of glucocorticoids has recently been reported as useful first-line therapy for eosinophilic esophagitis.
Journal
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- GASTROENTEROLOGICAL ENDOSCOPY
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GASTROENTEROLOGICAL ENDOSCOPY 53 (1), 3-15, 2011
Japan Gastroenterological Endoscopy Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204217920512
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- NII Article ID
- 10027866965
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- NII Book ID
- AN00192102
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- ISSN
- 18845738
- 03871207
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed