THE CLINICAL VALUE OF GLUCAGON FOR THE PREMEDICATION OF UPPER GASTROINTESTINAL ENDOSCOPY

DOI
  • TAKAYAMA TETSUO
    Department of Internal Medicine , Kamo Hospital, Toyota
  • KATO KATSUMOTO
    The second Department of Internal Medicine , School of Medicine, Nagoya University, Nagoya
  • KATADA NAOYUKI
    The second Department of Internal Medicine , School of Medicine, Nagoya University, Nagoya
  • NISHIMURA DAISAKU
    The second Department of Internal Medicine , School of Medicine, Nagoya University, Nagoya
  • SHIBATA TOKIMUNE
    The second Department of Internal Medicine , School of Medicine, Nagoya University, Nagoya
  • KATO KENYA
    The second Department of Internal Medicine , School of Medicine, Nagoya University, Nagoya
  • TAKEICHI MASAYUKI
    The second Department of Internal Medicine , School of Medicine, Nagoya University, Nagoya
  • HAYAKAWA TETSUO
    The second Department of Internal Medicine , School of Medicine, Nagoya University, Nagoya
  • KONDO TAKAHARU
  • SAKAKIBABA AKIRA

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Other Title
  • 胃内視鏡検査の前処置剤としてのグルカゴンの蠕動抑制効果

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Description

The clinical evaluation of glucagon for the premedication of upper gastrointestinal endoscopy was made to 172 patients. When the lowest dose of glucagon (0.5mg, intramusculary) was given, gastric motility was inhibited in 87.5% (27/32) of the cases at the start of endoscopical observation. The inhibition was continued for 15 minutes in 42.9% (3/7). The effect of glucagon in this dose on the gastric motility was equivalent to that of anticolinergic (butropium bromide, 4mg intramuscular injection). The inhibition of gastric motility was most prominent and prolonged in patients given 1.0mg of glucagon intravenously. Gastric motility was inhibited in 97.1% (34/35) of patients soon after the injection of glucagon and in 66.7%(8/12) at 15 minutes after the injection. No untoward effects of glucagon were noted. These results indicate glucagon an the drug of choice for premedication in upper gastrointestinal endoscopy.

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