IMPROVED MESENTERIC PHLEBOSCLEROSIS AFTER CEASATION OF CHINESE HERBAL MEDICINE, A CASE REPORT WITH AN OBSERVATION PERIOD OF 7 YEARS FROM ONSET

DOI
  • MIWA Wataru
    Division of Internal Medicine, Hiratsuka Gastroenterological Hospital.
  • HIRATSUKA Takashi
    Division of Internal Medicine, Hiratsuka Gastroenterological Hospital.
  • KAMIYA Yusuke
    Division of Internal Medicine, Hiratsuka Gastroenterological Hospital.
  • SHOJI Hidenori
    Division of Internal Medicine, Hiratsuka Gastroenterological Hospital.
  • TEI Syutetsu
    Division of Internal Medicine, Hiratsuka Gastroenterological Hospital.
  • DAIRAKU Katsuryo
    Division of Internal Medicine, Hiratsuka Gastroenterological Hospital.
  • SHIRAISHI Huminori
    Division of Internal Medicine, Hiratsuka Gastroenterological Hospital.
  • FUJIMOTO Taketoshi
    Division of Surgery, Hiratsuka Gastroenterological Hospital.
  • SATO Ken
    Division of Surgery, Hiratsuka Gastroenterological Hospital.
  • KATO Yo
    Department of Pathology, Nikko Medical Center, Dokkyo Medical University.

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Other Title
  • 発症から漢方薬服薬中止により改善まで7年間の経過観察が可能であった腸間膜静脈硬化症の1例

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Abstract

A 40-year-old woman, who attended our hospital in 2007, was diagnosed with idiopathic mesenteric phlebosclerosis (IMP) after stool abnormalities and a positive fecal occult blood test. Since 2000, she had been taking several Chinese herbal medicines, mainly orengedokuto and ryutansyakakuto, for the treatment of atopic dermatitis. After the initial diagnosis, we performed yearly examinations, including a colonoscopy, on the patient. Calcifications along the mesenteric vein on the right side of the colon, as detected by computed tomography (CT), progressed rapidly until 2009, when the patient was hospitalized due to an ileus associated with IMP. Since 2009, when the patient discontinued taking Chinese herbal medicine, her IMP steadily and markedly improved according to subsequent clinical examinations, and endoscopic and histologic findings; however, according to CT, calcifications along the mesenteric vein remained unchanged. This is a case report of improved IMP after the discontinuance of Chinese herbal medicine, with a long-term observation period of seven years after onset. This report is important in highlighting the association between the pathogenesis of IMP and Chinese herbal medicine.

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