Structural Elucidation of a Tadalafil Analogue Found in a Dietary Supplement
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- HASEGAWA Takashi
- Chiba Prefectural Institute of Public Health
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- SAIJO Masaaki
- Chiba Prefectural Institute of Public Health
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- ISHII Toshiyasu
- Chiba Prefectural Institute of Public Health
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- NAGATA Tomoko
- Chiba Prefectural Institute of Public Health
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- HAISHIMA Yuji
- National Institute of Health Sciences
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- KAWAHARA Nobuo
- National Institute of Health Sciences
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- GODA Yukihiro
- National Institute of Health Sciences
Bibliographic Information
- Other Title
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- 健康食品中から検出されたタダラフィル類縁物質の構造解析
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Abstract
A tadalafil analogue was detected in a dietary supplement marketed for tonic effect, along with hydroxyhomosildenafil and aminotadalafil. The tadalafil analogue was isolated by preparative thin layer chromatography (TLC) and its structure was elucidated using high-performance liquid chromatography (HPLC), liquid chromatography electrospray ionization-mass spectrometry (LC-ESI-MS), Fourier transform-ion cyclotron resonance-mass spectrometry (FT-ICR-MS) and nuclear magnetic resonance (NMR) spectroscopy. The compound was determined to be methyl-1-(1,3-benzodioxol-5-yl)-2-(chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate.
Journal
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- Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)
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Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 49 (4), 311-315, 2008
Japanese Society for Food Hygiene and Safety
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Details 詳細情報について
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- CRID
- 1390001204223561216
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- NII Article ID
- 10024453951
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- NII Book ID
- AN00117741
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- COI
- 1:CAS:528:DC%2BD1cXhtFSqtrrP
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- ISSN
- 18821006
- 00156426
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- NDL BIB ID
- 9649860
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- PubMed
- 18787317
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed