Effects of Veterinary Drugs on .BETA.-Hexosaminidase Release from Rat Basophilic Leukemia Cells (RBL-2H3).

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  • ラット好塩基球白血病細胞内のβ‐ヘキソサミニダーゼ遊離に及ぼす動物用医薬品の影響
  • 調査・資料 ラット好塩基球白血病細胞内のβ-ヘキソサミニダーゼ遊離に及ぼす動物用医薬品の影響
  • チョウサ シリョウ ラット コウエンキキュウ ハッケツビョウ サイボウ ナイ ノ ベータ ヘキソサミニダーゼ ユウリ ニ オヨボス ドウブツヨウ イヤクヒン ノ エイキョウ

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Abstract

Little is known about the effects of residual veterinary drugs on the allergic reaction, except for the antigenicity of antibiotics and synthetic antimicrobials. Therefore, 59 kinds of veterinary drugs were investigated for their effects on the IgE receptor-mediated β-hexosaminidase release from RBL-2H3 cells as an index of immediate allergic reaction.<br>We found that the antibiotics chlorotetracycline, doxycycline, monensin, the synthetic antimicrobial pyrimethamine and the steroid hormone testosterone inhibited β-hexosaminidase release. Most of the veterinary drugs showed no action, though the ionophores lasalocid, salinomycin and the steroid hormone hexestrol promoted β-hexosaminidase release from injured cells. Based on the residual levels of these drugs and the frequencies of detection in actual food samples, it seems unlikely that these drugs have any immediate allergic effect in practice.

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