Effect of Spices on .BETA.-Hexosaminidase Release from Rat Basophilic Leukemia Cells (RBL-2H3).
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- TANAKA Yukio
- Osaka Prefectural Institute of Public Health
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- KONISHI Yoshimasa
- Osaka Prefectural Institute of Public Health
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- TAKAGAKI Yutaka
- Osaka Prefectural Institute of Public Health
Bibliographic Information
- Other Title
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- ラット好塩基球白血病細胞からのβ‐ヘキソサミニダーゼ遊離に及ぼす香辛料の影響
- ラット好塩基球白血病細胞からのβ-ヘキソサミニダーゼ遊離に及ぼす香辛料の影響
- ラット コウ エンキキュウ ハッケツビョウ サイボウ カラ ノ ベータ ヘキソ
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Abstract
The effect of spices on immediate allergic reaction was evaluated using a newly developed assay method. Using rat basophilic leukemia cells (RBL-2H3) instead of the conventional method based on histamine release from mast cells, this method permits highly accurate mass screening since β-hexosaminidase is determined as the index of chemical mediator release and a good correlation exists between the amounts of β-hexosaminidase and histamine released from RBL-2H3 cells. Twenty-four spices were investigated for their effect on β-hexosaminidase release from RBL-2H3 cells stimulated with biotinylated IgE-avidin complex. Cinnamon, clove, Japanese pepper, garlic, bay leaves, oregano, thyme, sage and allspice showed release-inhibitory action. This inhibitory action was not caused by cell death. Thus, it appears that some spices exhibit antiallergic activity.
Journal
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- Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)
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Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 38 (1), 7-11, 1997
Japanese Society for Food Hygiene and Safety
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Keywords
Details 詳細情報について
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- CRID
- 1390001204224703616
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- NII Article ID
- 10009299798
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- NII Book ID
- AN00117741
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- ISSN
- 18821006
- 00156426
- http://id.crossref.org/issn/00156426
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- NDL BIB ID
- 4151956
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- Text Lang
- ja
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed